Lung Cancer: MicroRNA and Target Database

Challa KIRAN

Abstract


MicroRNAs (miRNAs) are a class of non-coding RNAs that hybridize to mRNAs and induce either translation repression ormRNA cleavage. Recently, it has been reported that miRNAs could possibly play a critical role in cellular processes like regulationof cell growth, differentiation, and apoptosis, emphasizing their role in tumorigenesis. Likewise, several miRNA’s are involvedin lung cancer tumorigenesis. The present review puts forth a database of human miRNA’s involved in lung cancer along withtheir target genes. It also provides sequences of miRNA’s and their chromosomal locations retrieved from different databases likemicroCosm (218 microRNAs), PhenomiR (293 microRNAs), and mir2Disease (90 microRNAs) and target gene informationsuch as the pathways like cell cycle regulation, angiogenesis, apoptosis etc. Though miRNA’s are still to be explored, they hold apromise as therapeutic targets and diagnostic markers of cancer.

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Published by: International Society for Translational Sciences(ISTS)

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