Tissue Carcinoembryonic Antigen, Calcium, Copper and Iron Levels in Cancerous Lung Patients

Nasar Yousuf ALWAHAIBI1


Background and objective The expression of various trace elements and markers in lung cancer is controversial. The aim ofthis study is to evaluate the presence of calcium (Ca), copper (Cu), iron (Fe) and carcinoembryonic antigen (CEA) in cancerousuntreated lung tissues and to determine a possible association between these markers and lung cancer.Methods Fourty-eight cancerous lung tissue blocks, from Sultan Qaboos University Hospital, Sultanate of Oman, were studied.Fe, Ca, Cu, and CEA were demonstrated in the tissue blocks using Perl's Prussian blue, Von Kossa's, modified rhodanine andimmunohistochemical staining methods, respectively.Results Twenty-three of 48 specimens showed positive Fe staining, 2 showed positive Ca staining and Cu was absent in allspecimens. 93.7% expressed CEA in varying degree of positivity. 81.25% of these sections showed high expression of CEA.Conclusion Tissue concentrations of trace elements were not elevated in lung cancer and therefore cannot be considered as apotential marker. Despite the low sensitivity and specificity of CEA as previously reported, tissue CEA should be considered as apotential marker in the evaluation of lung cancer.

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Published by: International Society for Translational Sciences(ISTS)

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